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Metal-directed hierarchical superhelices from hybrid peptide foldamers

Dey, S.; Roy, S.; Puneeth Kumar, D. R. G.; Nalawade, S. A.; Singh, M.; Toraskar, S. U.; Mahapatra, S. P.; Gopi, H. N.

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Chem. Commun. 2025, 61, 2770-2773​

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Exploring Macroscopic Dipoles of Designed Cyclic Peptide Ordered Assemblies to Harvest Piezoelectric Properties

 Mahapatra, S. P.; Pahan, S.; Chatterjee, A.; Roy, S.; Puneeth Kumar, D. R.; Gopi, H. N.

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Angew. Chem. Int. Ed. 2024, 63, e202409969

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Crystal structure analysis of helix–turn–helix type motifs in α,γ-hybrid peptides

Ganesh Kumar, M.; Dey, S.; Singh, M.; Puneeth Kumar, D. R.; Nalawade, S. A.; Gopi, H. N

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CrystEngComm 2024, 26, 913-917

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Design of Chiral β-Double Helices from γ-Peptide Foldamers

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Pahan, S.; Dey, S.; George, G.; Panda Mahapatra, S.; Koppalu R. Puneeth Kumar, D. R. G.; Gopi, H. N. 

 

Angew. Chem. Int. Ed.  2024, 63, e202316309

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Anion Tuned Structural Modulation and Nonlinear Optical Effects of Metal-Ion Directed 3₁₀-Helix Networks

Roy, S.; Chaturvedi, A.; Dey, S.; Puneeth Kumar, D. R.; Pahan, S.; Panda Mahapatra, S.; Mandal, P.; Gopi, H. N. 

 

Chem. Eur. J. 2023, 29, e202303135

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HBTU Mediated Synthesis of α,β-Unsaturated γ-Lactams from E-α,β-Unsaturated γ-Amino Acids

Singh, M.; Nalawade, S. A.; Puneeth Kumar, D. R.; Veeresh, K.; Pahan, S.; Dey, S.; Gopi, H. N.

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Eur. J. Org. Chem. 2023, 26, e202300682

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Proteolytically Stable ααγ-Hybrid Peptides Inhibit the Aggregation and Cytotoxicity of Aβ42

Puneeth Kumar, D. R.; Nalawade, S. A.; Pahan, S.; Singh, M.; Senapati, D. K.; Roy, S.; Dey, S.; Toraskar, S. U.; Raghothama, S.; Gopi, H. N.

 

ACS Chem. Neurosci. 2023, 14, 3398–3408

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Foldamer Nanotubes Mediated Label‐Free Detection of Protein–Small Molecule Interactions

Puneeth Kumar, D. R.; Bhat, Z. M.; Dey, S.; Roy, S.; Panda Mahapatra, S.; Pahan, S.; Thotiyl, M. O.; Gopi, H. N.

 

Chem. Eur. J. 2023, 29, e202300479

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Cyclization of N-Boc-(E)-α,β-Unsaturated γ-Amino Acid Active Esters into N-Boc-(Z)-α,β-Unsaturated γ-Lactams through E → Z Isomerization

Singh, M.; Kumar, M.; Nalawade, S. A.; Puneeth Kumar, D. R.; Gopi, H. N.

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Org. Biomol. Chem. 2023, 21, 3766–3769

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Stereoselective synthesis of backbone extended π-conjugated amino esters

Nalawade, S. A.; Singh, M.; Puneeth Kumar, D. R.; Dey, S.; Gopi, H. N.  

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Org. Biomol. Chem. 2023, 21, 2586-2595

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A cationic amphiphilic peptide chaperone rescues Aβ42 aggregation and cytotoxicity

Puneeth Kumar, D. R.; Reja, R. M.; Senapati, D. K.; Singh, M.; Nalawade, S. A.; George, G.; Kaul, G.; Akhir, A.; Chopra, S.; Raghothama, S.; Gopi, H. N.


RSC Med. Chem. 2023, 14, 332–340

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Metal-Coordinated Supramolecular Polymers from the Minimalistic Hybrid Peptide Foldamers

Dey, S.; Misra, R.; Saseendran, A.; Pahan, S.; Gopi, H. N.


Angew. Chem. 2021,133, 9951–9956
 

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Structural Investigation of Hybrid Peptide Foldamers Composed of α‐Dipeptide Equivalent β‐Oxy‐δ5‐amino Acids

Reja, R. M.; Kumar, V.; George, G.; Patel, R.; Puneeth Kumar, D. R.; Raghothama, S.; Gopi, H. N.


Chem. Eur. J. 2020, 26, 4304–4309

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Structural insight into hybrid peptide ε-helices

Misra, R.; George, G.; Reja, R. M.; Dey, S.; Raghothama, S.; Gopi, H. N.


Chem. Commun. 2020, 56, 2171–2173

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Ambidextrous α, γ‐Hybrid Peptide Foldamers

Misra, R.; George, G.; Saseendran, A.; Raghothama, S.; Gopi, H. N.


Chem. Asian J. 2019, 14, 4408–4414

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Direct Transformation of N-Protected α,β-Unsaturated γ-Amino Amides into γ-Lactams through a Base-Mediated Molecular Rearrangement

Kumar, M. G.; Veeresh, K.; Nalawade, S. A.; Nithun, R. V.; Gopi, H. N.
 

J. Org. Chem. 2019, 84, 15145–15153

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Design of Helical Peptide Foldamers through α,β → β,γ Double-Bond Migration

Veeresh, K.; Gopi, H. N.


Org. Lett. 2019, 21, 4500–4504

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Metal-Helix Frameworks from Short Hybrid Peptide Foldamers

Misra, R.; Saseendran, A.; Dey, S.; Gopi, H. N.


Angew. Chem. 2019, 131, 2273–2277

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Divergent supramolecular gelation of backbone modified short hybrid δ-peptides

Reja, R. M.; Patel, R.; Kumar, V.; Jha, A.; Gopi, H. N.


Biomacromolecules 2019, 20, 1254–1262

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Engineering Two-Helix Motifs through NDI Linker: A Modular Approach for Charge Transferable Conductive Foldamers Design

Reja, R. M.; Misra, R.; Gopi, H. N.


ChemNanoMat  2019, 5, 51–54

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Artificial β‐double helices from achiral γ‐peptides

Misra, R.; Dey, S; Reja, R. M.; Gopi, H. N.


Angew. Chem. 2018, 130, 1069–1073

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Modulating the Structural Properties of α,γ-Hybrid Peptides by α-Amino Acid Residues: Uniform 12-Helix Versus “Mixed” 12/10-Helix

Misra, R.; Raja, K. M. P.; Hofmann, H.-J.; Gopi, H. N.


Chem. Eur. J. 2017, 23, 16644–16652

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Potent Antimicrobial Activity of Lipidated Short α,γ-Hybrid Peptides

Benke, S. N.; Thulasiram, H. V.; Gopi, H. N.


ChemMedChem 2017, 12, 1610–1615

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Backbone engineered γ-peptide amphitropic gels for immobilization of semiconductor quantum dots and 2D cell culture

Misra, R.; Sharma, A.; Shiras, A.; Gopi, H. N.


Langmuir 2017, 33, 7762–7768

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Chemoselective Nitrile Oxide–Alkyne 1, 3-Dipolar Cycloaddition Reactions from Nitroalkane-Tethered Peptides

Reja, R. M.; Sunny, S.; Gopi, H. N.


Org. Lett. 2017, 19, 3572–3575

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Structural Dimorphism of Achiral α, γ‐Hybrid Peptide Foldamers: Coexistence of 12‐and 15/17‐Helices

Misra, R.; Saseendran, A.; George, G.; Veeresh, K.; Poopathi Raja, K. M.; Raghothama, S.; Hofmann, H.-J.; Gopi, H. N.


Chem. Eur. J. 2017, 23, 3764–3772

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Helices with additional H-bonds: crystallographic conformations of α,γ-hybrid peptides helices composed of β-hydroxy γ-amino acids (statines)

Malik, A.; Kumar, M. G.; Bandyopadhyay, A.; Gopi, H. N.

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Peptide Science 2017;108:e22978

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Structural features and molecular aggregations of designed triple-stranded β-sheets in single crystals

Bandyopadhyay, A.; Misra, R.; Gopi, H. N.


Chem. Commun. 2016, 52, 4938–4941

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Exploring structural features of folded peptide architectures in the construction of nanomaterials

Misra, R.; Reja, R. M.; Narendra, L. V.; George, G.; Raghothama, S.; Gopi, H. N.


Chem. Commun. 2016, 52, 9597–9600

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Patent- Inhibition of HIV-1 Infection by Potent Metallocene Conjugated Peptide Through Conformational Entrapment of Envelope GP120

Gopi, H. N.; Chaiken, I. M.
 

 U.S. Patent US 14329359, Jan 8, 2015

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γ-and β-Peptide Foldamers from Common Multifaceted Building Blocks: Synthesis and Structural Characterization

Kumar, M. G.; Gopi, H. N.


Organic Lett. 2015, 17, 4738–4741

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Foldamers to Nanotubes: Influence of Amino Acid Side Chains in the Hierarchical Assembly of α,γ4‐Hybrid Peptide Helices

Jadhav, S. V.; Misra, R.; Gopi, H. N.


Chem. Eur. J. 2014, 20, 16523–16528

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Exploring β-Hydroxy γ-Amino Acids (Statines) in the Design of Hybrid Peptide Foldamers

Bandyopadhyay, A.; Malik, A.; Kumar, M. G.; Gopi, H. N. 

 

Org. Lett. 2014, 16, 294–297

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HBTU mediated 1-hydroxybenzotriazole (HOBt) conjugate addition: synthesis and stereochemical analysis of β-benzotriazole N-oxide substituted γ-amino acids and hybrid peptides

Mali, S. M.; Kumar, M. G.; Katariya, M. M.; Gopi, H. N. 

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Org. Biomol. Chem. 2014, 12, 8462–8472

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Efficient Access to Enantiopure γ4‐Amino Acids with Proteinogenic Side‐Chains and Structural Investigation of γ4‐Asn and γ4‐Ser in Hybrid Peptide Helices

Jadhav, S. V.; Misra, R.; Singh, S. K.; Gopi, H. N.

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Chem. Eur. J. 2013, 19, 16256–16262

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Self-Assembly to Function: Design, Synthesis, and Broad Spectrum Antimicrobial Properties of Short Hybrid E-Vinylogous Lipopeptides

Shankar, S. S.; Benke, S. N.; Nagendra, N.; Srivastava, P. L.; Thulasiram, H. V.; Gopi, H. N.

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J. Med. Chem. 2013, 56, 8468–8474

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Thioacids mediated selective and mild N-acylation of amines

Mali, S. M., Bhaisare, R. D., Gopi, H. N.

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J. Org. Chem. 2013, 78, 5550–5555

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A Designed Three‐Stranded β‐Sheet in an α/β Hybrid Peptide

Sonti, R.; Gopi, H. N.; Muddegowda, U.; Ragothama, S.; Balaram, P

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Chem. Eur. J. 2013, 19, 5955 – 5965 

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γ-Amino acid mutated α-coiled coils as mild thermal triggers for liposome delivery

Jadhav, S. V.; Singh, S. K.; Reja, R. M.; Gopi, H. N. 

 

Chem. Commun. 2013, 49, 11065–11067

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Remarkable thermoresponsive nanofibers from γ-peptides

Jadhav, S. V.; Gopi, H. N.

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Chem. Commun. 2013, 49, 9179–9181

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Thiazole–carbonyl interactions: A case study using phenylalanine thiazole cyclic tripeptides

Mali, S. M.; Schneider, T. F.; Bandyopadhyay, A.; Jadhav, S. V.; Werz, D. B.; Gopi, H. N

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 Cryst. Growth Des. 2012, 12, 5643–5648

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Hybrid peptides: Direct transformation of α/α, β-unsaturated γ-hybrid peptides to α/γ-hybrid peptide 12-helices

Bandyopadhyay, A.; Gopi, H. N.

 

Org. Lett. 2012, 14 , 2770–2773

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Antiviral Breadth and Combination Potential of Peptide Triazole HIV-1 Entry Inhibitors

McFadden, K.; Fletcher, P.; Rossi, F.; Kantharaju; Umashankara, M.; Pirrone, V.; Rajagopal, S.; Gopi, H.; Krebs, F. C.; Martin‑Garcia, J.; Shattock, R. J.; Chaiken, I.

 

Antimicrob. Agents Chemother. 2012, 56, 1073–1080

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Dual inhibitors of HIV-1 gp-120 interactions

Gopi, H.; Chaiken, I. 

 

U.S. Patent 8,092,805 B2, issued January 10, 2012; Application No. 12/638,725 (filed December 15, 2009). Philadelphia Health and Education Corporation.

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Copper(ii) mediated facile and ultra fast peptide synthesis in methanol

Mali, S. M., Jadhav, S. V., Gopi, H. N.

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Chem. Commun. 2012, 48, 7085-7087

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α/γ4-Hybrid peptide helices: synthesis, crystal conformations and analogy with the α-helix

Bandyopadhyay, A., Jadhav, S. V., Gopi, H. N.

 

Chem. Commun. 2012, 48, 7170–7172

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Synthesis and structural investigations of functionalizable hybrid β-hairpin

Bandyopadhyay, A.; Mali, S. M.; Lunawat, P.; Raja, K. M. P.; Gopi, H. N.

 

Org. Lett. 2011, 13, 4482–4485

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Jadhav, S. V.; Bandyopadhyay, A.; Benke, S. N.; Mali, S. M.; Gopi, H. N

 

Org. Biomol. Chem. 2011, 9, 4182–4187

A facile synthesis and crystallographic analysis of N-protected β-amino alcohols and short peptaibols

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A facile transformation of amino acids to functionalized coumarins

Bandyopadhyay, A.; Gopi, H. N.

 

Org. Biomol. Chem. 2011, 9, 8089–8095

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